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tRNA-derived RNAs that form tetramolecular assemblies

Prakash Kharel1

  • 1Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.

Methods in Enzymology
|February 14, 2025
PubMed
Summary

Transfer RNA (tRNA)-derived small RNAs (tDRs) can form stable tetramolecular assemblies. These structures, driven by guanine-rich motifs, offer new insights into gene regulation and RNA therapeutics.

Keywords:
G-quadruplexTerminal oligonucleotide motifTetramolecular assemblyTranslation regulationtDRstiRNAs

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