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Relation between vitamin D deficiency and Pseudomonas aeruginosa colonization in patients with bronchiectasis

Yu-Hua Wen1, Ruo-Xuan Dai1, Heng Yang1

  • 1Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, China.

BMC Pulmonary Medicine
|February 14, 2025
PubMed
Abstract

Insights

Vitamin D deficiency is common in bronchiectasis patients and linked to increased Pseudomonas aeruginosa colonization. Vitamin D may offer protection by reducing bacterial survival and inflammation.

Area of Science:

  • Pulmonary Medicine
  • Microbiology
  • Immunology

Background:

  • The link between vitamin D deficiency and Pseudomonas aeruginosa colonization in bronchiectasis remains unclear.
  • Bronchiectasis patients often experience chronic bacterial infections, with P. aeruginosa being a common pathogen.

Purpose of the Study:

  • To investigate the association between vitamin D levels and P. aeruginosa colonization in bronchiectasis.
  • To explore the in vitro effects of vitamin D on P. aeruginosa infection and host immune response.

Main Methods:

  • Serum 25-hydroxyvitamin D levels and clinical data were collected from 195 bronchiectasis patients.
  • Correlation and logistic regression analyses were used to assess the relationship between vitamin D and P. aeruginosa colonization.
  • In vitro studies examined the impact of 1,25-dihydroxyvitamin D on P. aeruginosa-infected macrophages.

Main Results:

  • 83.1% of patients had vitamin D deficiency, which correlated with higher P. aeruginosa colonization rates.
  • Vitamin D deficiency and female gender were risk factors for P. aeruginosa colonization.
  • Vitamin D inhibited bacterial phagocytosis and reduced IL-1β secretion in vitro.

Conclusions:

  • Vitamin D deficiency is a significant risk factor for P. aeruginosa colonization in bronchiectasis.
  • Vitamin D exhibits protective effects against P. aeruginosa infection and associated inflammation.
Keywords:
Pseudomonas aeruginosaBronchiectasisIL-1βVitamin D

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