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Perceived HBV-Related Stigma Is Associated With Lower Antiviral Medication Adherence in Patients With Chronic

Hee-Soon Juon1, Daniel Yang1, Cindy Xin Fang1

  • 1Department of Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Journal of Viral Hepatitis
|February 15, 2025
PubMed

Insights

Medication adherence in Korean Americans with chronic hepatitis B (CHB) is influenced by age, knowledge of CHB, and perceived stigma. Improving adherence requires addressing personal and healthcare factors for better liver disease management.

Area of Science:

  • Hepatology
  • Public Health
  • Behavioral Science

Background:

  • Medication nonadherence in chronic hepatitis B (CHB) patients can accelerate liver disease progression to cirrhosis and hepatocellular carcinoma (HCC).
  • Understanding adherence factors in high-risk ethnic groups, such as Korean Americans, is crucial for effective management.

Purpose of the Study:

  • To investigate the psychosocial and clinical factors influencing medication adherence in Korean American patients with CHB.
  • To identify specific determinants of adherence to antiviral therapy in this population.

Main Methods:

  • A cohort of 365 Korean American CHB patients from Philadelphia and Los Angeles was surveyed.
  • The 8-item Morisky Medication Adherence Scale (MMAS-8) assessed adherence to antiviral medications.
  • Descriptive and multivariable logistic regression analyses identified factors associated with MMAS-8 scores.

Main Results:

  • 78% of participants received antiviral therapy, with 69% showing medium to high adherence.
  • Older age, greater knowledge of CHB sequelae, lower perceived HBV stigma, and having a pharmacy plan were linked to higher medication adherence.
  • Younger age, less knowledge, higher stigma, and lack of pharmacy plans were associated with lower adherence.

Conclusions:

  • Personal factors like knowledge of CHB and perceived stigma, alongside healthcare factors such as pharmacy plans, significantly impact medication adherence.
  • Targeted educational interventions focusing on these personal factors are recommended to improve adherence among Korean American CHB patients.

Keywords:
Asian AmericansCHB patientsKorean AmericansMMAS‐8medication adherence

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