Related Experiment Video
Updated: May 27, 2025
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
Published on: December 19, 2019
Season and weather factors matter, but not enough: a machine learning-based study on predicting incremental lifetime
Chenjia Li1, Yuxiang Deng1, Nuo Chen1
1Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, P. R. China.
Abstract:
With the intensification of urbanization, air pollution has garnered global concern. This study aims to predict the incremental lifetime cancer risk (ILCR) of polycyclic aromatic hydrocarbons (PAHs) in atmospheric PM2.5. Utilizing machine learning regression algorithms and data from six cities in Jiangsu Province in 2018, we established models to investigate the relationship between ILCR and various factors, with a special emphasis on seasonal and meteorological data. After model training, SHapley Additive exPlanation (SHAP) analysis revealed that seasonal factors were even more influential than PM2.5 in predicting ILCR. Models were then validated using 2019 data, resulting in an R2 of 0.42, which indicated a decrease in accuracy compared to the 2018 test set R2 of 0.74 but still represented an improvement over using PM2.5 alone (R2 = 0.2). This suggests that while seasonal and related factors are crucial, additional factors are needed to build a robust model for future ILCR predictions.
More Related Videos
11:38High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC
Published on: May 10, 2016
12:15Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
Published on: May 29, 2019
Related Concept Videos
Cancer Prevention
Some...
Statistical Methods for Analyzing Epidemiological Data
Mutagenicity and Carcinogenicity
Cancer Survival Analysis