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Changes in chemotherapy-induced cognitive impairment in gastrointestinal cancer survivors using multidomain assessments: a prospective cohort study

  • 0Department of Psychosocial Rehabilitation, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan. saita@hiroshima-u.ac.jp.
Journal of Cancer Survivorship : Research and Practice +

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February 15, 2025

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February 15, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Gastrointestinal cancer survivors undergoing chemotherapy may experience memory deficits. Functional near-infrared spectroscopy (fNIRS) is a feasible tool for monitoring brain activity and understanding cancer-related cognitive impairment (CRCI).

Area Of Science

  • Neuroscience
  • Oncology
  • Cognitive Psychology

Background

  • Cancer-related cognitive impairment (CRCI) presents diverse risk factors.
  • Neuroimaging is recommended to complement subjective and objective cognitive assessments.
  • Evaluating CRCI in gastrointestinal cancer survivors requires robust assessment protocols.

Purpose Of The Study

  • To assess the feasibility of a multidomain assessment protocol for CRCI in gastrointestinal cancer survivors.
  • To investigate cognitive function and cerebral hemodynamics in chemotherapy patients.
  • To establish a baseline for future CRCI research in cancer survivors.

Main Methods

  • 24 gastrointestinal cancer patients and 24 healthy controls were recruited.
  • Cognitive function was assessed using FACT-Cog, Trail Making Test, AVLT, and verbal fluency.
  • Cerebral hemodynamic changes in the prefrontal cortex were measured using portable functional near-infrared spectroscopy (P-NIRS).

Main Results

  • A significant difference in auditory verbal learning test (AVLT)-delayed recall was observed in the chemotherapy group compared to controls (p=0.002).
  • The chemotherapy group showed reduced left frontal pole activity at 6 months post-treatment (p=0.018).
  • No significant differences were found in other cognitive assessments between groups.

Conclusions

  • Gastrointestinal cancer survivors receiving chemotherapy may have impaired memory recall.
  • P-NIRS monitoring of prefrontal cortex hemodynamics is feasible for clinical application in CRCI.
  • Multidomain assessments are translatable to clinical practice and beneficial for understanding CRCI impacts.

Keywords:

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