Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

10.3K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
10.3K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Charting New Territory: Systematic Evaluation of the Drug Potential of <i>N</i>-Trifluoromethyl Amides, Ureas & Carbamates.

Journal of medicinal chemistry·2026
Same author

Zebrafish as an Anti-Isogenic Vertebrate Model and What It Reveals About Genetic Background and Reproducibility.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same author

Thiourea-based multifunctional fluorescent materials: From metal and anion detection to antibacterial polymer films.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026
Same author

Critical role of Cas9 aggregation on in vitro DNA cleavage.

International journal of biological macromolecules·2026
Same author

Methylene-Linked Triazolylidenes as Cooperative Ligands in Manganese-Catalyzed <i>N</i>-Alkylation.

Inorganic chemistry·2026
Same author

Self-Assembly and Crystal Structure of Boc-Protected Dipeptides Containing L-Phenylalanine and L-Tyrosine.

Materials (Basel, Switzerland)·2026
Same journal

Stabilizing Pd Catalysts on Pentacoordinated Al<sup>3+</sup> Sites of Alumina for Efficient Hydrogenation of Hexafluoropropylene.

ChemPlusChem·2026
Same journal

Design, Synthesis, and Performance Characterization of BODIPY-Based NIR Probes for Aβ<sub>42</sub> Aggregate Detection.

ChemPlusChem·2026
Same journal

Eliminate the Metal Ion in the Edible Oil Based on High Extraction pH-Switchable Deep Eutectic Solvents.

ChemPlusChem·2026
Same journal

Cinoplatin: An Efficient Platinum(IV) Prodrug Effective in Inhibiting the Growth of Cervical Cancer.

ChemPlusChem·2026
Same journal

A Mitochondria-Targeted Flavokawain A Derivative Suppresses Lymphoma by Disrupting Oxidative Phosphorylation.

ChemPlusChem·2026
Same journal

CALPUCK: An Open Python Tool for Cremer-Pople Ring Puckering Analysis Including a New 2D Mapping of Seven-Membered Rings.

ChemPlusChem·2026
See all related articles

Related Experiment Video

Updated: May 27, 2025

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
10:51

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes

Published on: April 10, 2015

12.1K

Triazole-Derived Ruthenium(II) Complexes as Novel Candidates for Cancer Therapy.

Oscar A Lenis-Rojas1, Catarina Roma-Rodrigues2, Beatriz Carvalho2

  • 1Instituto de Tecnologia Química e Biológica António Xavier, ITQB NOVA, Av. da República, 2780-157, Oeiras, Portugal.

Chempluschem
|February 15, 2025
PubMed
Summary
This summary is machine-generated.

New ruthenium (Ru) complexes show promise as anticancer agents. These compounds effectively target and reduce tumor cell proliferation, with one variant demonstrating high selectivity for cancer cells and minimal toxicity to healthy cells in zebrafish models.

Keywords:
CAM assayanticancerrutheniumtriazolylideneszebrafish xenograft

More Related Videos

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

13.9K
Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
05:17

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

1.5K

Related Experiment Videos

Last Updated: May 27, 2025

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
10:51

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes

Published on: April 10, 2015

12.1K
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

13.9K
Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
05:17

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

1.5K

Area of Science:

  • Organometallic Chemistry
  • Medicinal Chemistry
  • Cancer Research

Background:

  • Ruthenium (Ru) complexes are explored for their therapeutic potential.
  • Triazolylidene-triazolide ligands offer unique coordination properties for metal complexes.

Purpose of the Study:

  • To synthesize and characterize novel Ru(II) η6-arene complexes with a bidentate triazolylidene-triazolide ligand.
  • To evaluate the antiproliferative activity and selectivity of these complexes against various cancer cell lines and in vivo models.

Main Methods:

  • Synthesis and full characterization of Ru(II) η6-arene complexes.
  • In vitro antiproliferative assays against ovarian and colorectal cancer cell lines (including drug-resistant variants) and human dermal fibroblasts.
  • In vivo studies using zebrafish models to assess anticancer efficacy and toxicity.

Main Results:

  • Both synthesized Ru complexes demonstrated antiproliferative effects.
  • The p-cymene Ru complex showed stronger overall antiproliferative activity, while the benzene complex exhibited higher tumor cell selectivity.
  • Complexes induced apoptosis, inhibited cell migration and angiogenesis, and showed significant cancer cell targeting with low toxicity in zebrafish.

Conclusions:

  • Novel Ru(II) triazolylidene-triazolide complexes possess significant anticancer properties.
  • The study provides the first in vivo evidence of anticancer potential for Ru triazolylidenes in zebrafish models.
  • These findings highlight the therapeutic promise of these Ru complexes for cancer treatment.