Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

1.2K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
1.2K
Aging01:26

Aging

35
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
35

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Huge analysis of 320,000 careers suggests that productive researchers stay that way.

Nature·2026
Same author

Now is the time for scientific societies to guide global research.

Nature·2026
Same author

High-Throughput In Vivo Subcellular Analysis of Gold Nanoparticles for Tumor Mitochondrial Targeting.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Nanostraw Electroporation for Temporal RNA Sampling from Living 2D and 3D Cell Culture Systems.

ACS nano·2025
Same author

Military regenerative medicine.

Biomaterials science·2025
Same author

Universities can do more to prepare the biomedical workforce for the cell-, tissue- and gene-manufacturing industry.

Cytotherapy·2025
Same journal

Age-Associated Senescence of Decidual Macrophages: A Key Mediator of Adverse Pregnancy Outcomes in Advanced Maternal Age.

Aging cell·2026
Same journal

Correction to "Telomerase Knockout in Myeloid Cells Predisposes Mice to Foam Cell Formation, Dyslipidemia, Lung Fibrosis, and Cardiac Dysfunction".

Aging cell·2026
Same journal

Bidirectional Relationship and Shared Mechanisms Between Sarcopenia and Osteoporosis: An Observational Study Integrating Genomic, Proteomic, and Metabolomic Data.

Aging cell·2026
Same journal

Clonal Analyses Reveal the Impact of Hematopoietic Stem and Progenitor Cell Aging on T Cell Development.

Aging cell·2026
Same journal

A Gut-Centric View of Ageing: A Pilot Analysis Mapping Age-Associated Immune and Molecular Alterations in Colonic Mucosa Using Spatial Proteomics.

Aging cell·2026
Same journal

Correction to "Environmental Enrofloxacin Exposure as a Modifiable Driver of Mitochondria-Mediated Intestinal Aging and Barrier Dysfunction".

Aging cell·2026
See all related articles

Related Experiment Video

Updated: May 27, 2025

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
09:10

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin

Published on: December 16, 2013

6.0K

Exploring Lymph Node Stroma Ageing: Immune Implications and Future Directions.

Yu Yang Ng1, Andy Tay1,2,3

  • 1Department of Biomedical Engineering, National University of Singapore, Singapore City, Singapore.

Aging Cell
|February 15, 2025
PubMed
Summary
This summary is machine-generated.

Aging impairs immune function by affecting lymph node stromal cells (LNSCs). This review explores LNSC aging, its impact on immune responses, and potential therapeutic strategies for older adults.

Keywords:
ageingimmunityinfectionslymph nodestromal cells

More Related Videos

Isolation of Murine Lymph Node Stromal Cells
05:47

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

31.2K
Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses
09:55

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses

Published on: February 3, 2022

6.8K

Related Experiment Videos

Last Updated: May 27, 2025

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
09:10

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin

Published on: December 16, 2013

6.0K
Isolation of Murine Lymph Node Stromal Cells
05:47

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

31.2K
Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses
09:55

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses

Published on: February 3, 2022

6.8K

Area of Science:

  • Immunology
  • Gerontology
  • Cell Biology

Background:

  • Aging leads to immunosenescence and inflammaging, increasing susceptibility to diseases in individuals over 65.
  • Lymph node stromal cells (LNSCs) are vital for maintaining lymph node structure and immune function.
  • Age-related changes in LNs, including fibrosis and lipomatosis, impair immune cell function and responses.

Purpose of the Study:

  • To review the aging process of lymph node stromal cells (LNSCs).
  • To discuss the structural and functional decline of LNSC subsets (FRCs, LECs, BECs) with age.
  • To explore strategies for restoring aged LNSC function and address knowledge gaps.

Main Methods:

  • Literature review focusing on age-related changes in LNSCs.
  • Analysis of the impact of LNSC aging on lymph node architecture and immune homeostasis.
  • Exploration of potential therapeutic interventions for aged LNSCs.

Main Results:

  • Aging causes structural and functional decline in LNSCs, disrupting lymph node integrity.
  • Impaired LNSC function reduces immune cell recruitment and effectiveness, impacting infection and vaccination responses.
  • Fibrosis and lipomatosis are key age-related changes affecting lymph node structure and function.

Conclusions:

  • Aging significantly impacts LNSC subsets, leading to reduced immune surveillance and function.
  • Strategies like enhancing LNSC activation and senotherapeutics may restore immune function in older adults.
  • Further research is needed to understand LNSC aging mechanisms and their role in autoimmune disorders.