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Histones are critical toxic factors in gut lymph of severe acute pancreatitis: Neutralization by baicalin and baicalein for protection

  • 0West China Centre of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Phytomedicine : International Journal of Phytotherapy and Phytopharmacology +

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February 15, 2025

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February 15, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Histones in gut lymph contribute to organ failure in severe acute pancreatitis (SAP). Chaiqin chengqi decoction (CQCQD), particularly baicalin and baicalein, reduces histone toxicity and alleviates organ injury.

Area Of Science

  • Gastroenterology
  • Toxicology
  • Pharmacology

Background

  • Circulating histones in gut lymph are implicated in severe acute pancreatitis (SAP) and subsequent organ failure.
  • The therapeutic potential of chaiqin chengqi decoction (CQCQD) in modulating these histone effects remains unexplored.

Purpose Of The Study

  • To investigate the role of gut lymph histones in SAP-induced organ injury.
  • To evaluate the efficacy of CQCQD in mitigating histone-mediated toxicity in SAP.

Main Methods

  • Severe acute pancreatitis (SAP) was induced in rodents via sodium taurocholate infusion.
  • Gut lymph was collected dynamically from rats treated with various CQCQD regimens.
  • Endothelial cell viability, lymphocyte function, and CQCQD component interactions with histones were assessed.

Main Results

  • Elevated gut lymph histone levels in SAP correlated with multiple organ injury (MOI) and reduced cell viability.
  • CQCQD treatment decreased histone levels, protected against cell death, and reduced SAP-induced MOI.
  • Baicalin and baicalein, identified CQCQD components, directly bound histones, inhibited lymphocyte cytotoxicity, and mitigated SAP-induced organ injury in mice.

Conclusions

  • Histones in gut lymph are critical mediators of SAP-induced organ damage.
  • Antagonism of histones by baicalin and baicalein presents a promising therapeutic avenue for SAP.

Keywords:

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