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Tailoring organ dysfunction criteria for critically ill children with cancer

Roelie M Wösten-van Asperen1, Melissa R Hines2, Luregn J Schlapbach3

  • 1Department of Pediatric Intensive Care, University Medical Centre Utrecht, Wilhelmina Children's Hospital, Utrecht, Netherlands.

The Lancet. Child & Adolescent Health
|February 15, 2025
PubMed
Abstract

No abstract available in PubMed .

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The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
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Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
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