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Related Experiment Video

Updated: May 27, 2025

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

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Published on: June 5, 2020

Genotoxic risks in patients with COVID-19.

Nurşen Başaran¹, Olga Szewczyk-Roszczenko², Piotr Roszczenko³

¹Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Başkent University, Ankara 06790, Türkiye.

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases

|February 15, 2025

Summary

The COVID-19 pandemic may lead to genotoxicity and cancer. Studies show increased DNA damage in severe COVID-19 patients, linked to SARS-CoV-2 spike proteins and impaired DNA repair.

Keywords:

COVID-19 Comet assay DNA damage Genotoxicity SARS-CoV-2

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Area of Science:

Oncology
Virology
Genetics

Background:

The COVID-19 pandemic has caused significant global mortality.
Long-term consequences, including genotoxicity and neoplasm development, remain a concern.
This review addresses the potential for DNA damage and cancer following SARS-CoV-2 infection.

Purpose of the Study:

To review current data on genotoxicity in COVID-19 patients.
To explore the role of SARS-CoV-2 in DNA damage and repair inhibition.
To assess DNA damage as a prognostic factor for COVID-19 outcomes.

Main Methods:

Systematic review of international studies on COVID-19 and DNA damage.
Analysis of reported DNA damage levels in nucleated blood cells.
Evaluation of the impact of SARS-CoV-2 spike proteins and viral inhibition of DNA repair.

Main Results:

Multiple studies report elevated DNA damage in severe COVID-19 cases.
DNA damage levels correlate with disease severity and prognosis.
SARS-CoV-2 spike proteins are implicated in causing DNA damage.
The virus appears to inhibit the body's DNA repair mechanisms.

Conclusions:

COVID-19 infection is associated with significant genotoxicity.
DNA damage serves as a potential prognostic biomarker for COVID-19.
Further research is needed to understand the long-term oncogenic risks.