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Related Experiment Videos

Effect of sustained release isosorbide dinitrate on exercise performance.

M Y Flugelman, A Shefer, Y Ben David

    Cardiology
    |January 1, 1985
    PubMed
    Summary
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    Sustained-release isosorbide dinitrate (ISDSR) significantly improved exercise tolerance for over 10 hours in patients with effort angina. Dual dosing of ISDSR demonstrated more pronounced antianginal and hemodynamic benefits, enhancing blood pressure and heart rate regulation.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Effort angina pectoris significantly impacts patient quality of life.
    • Understanding the sustained efficacy and hemodynamic effects of nitrate formulations is crucial for effective angina management.

    Purpose of the Study:

    • To evaluate the duration of action and hemodynamic mechanisms of isosorbide dinitrate in a sustained-release formula (ISDSR).
    • To compare the effects of single versus double dosing of ISDSR in patients with effort angina.

    Main Methods:

    • A randomized study involving 20 patients with effort angina pectoris.
    • Patients received either a single 40 mg dose or two 40 mg doses of ISDSR over 24 hours.
    • Exercise tolerance was assessed using exercise tests on placebo and ISDSR days.

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    Main Results:

    • ISDSR significantly improved effort tolerance (p < 0.05) for over 10 hours.
    • Hemodynamic improvements were characterized by decreased blood pressure and increased heart rate.
    • Double-dosed ISDSR showed more pronounced antianginal and hemodynamic effects compared to single dosing.
    • No increased ischemia (ST segment depression) was observed with prolonged exercise.

    Conclusions:

    • ISDSR provides a prolonged antianginal effect in patients with effort-induced angina.
    • Sustained reduction in blood pressure and increase in heart rate contribute to improved effort tolerance.
    • A double-dose regimen of ISDSR offers enhanced therapeutic benefits.