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Predictive value of perioperative fasting blood glucose for post pancreatectomy diabetes mellitus in pancreatic ductal carcinoma patients

  • 0Department of General Surgery, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, N1 Shangcheng Road, Yiwu, Zhejiang, 322000, China.
World Journal of Surgical Oncology +

|

February 15, 2025

|

February 15, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Postpancreatectomy diabetes mellitus (PPTDM) is a significant complication after pancreatic cancer surgery. Elevated perioperative fasting blood glucose (FBG) levels are associated with increased risk and poorer prognosis, suggesting early intervention is crucial.

Area Of Science

  • Oncology
  • Endocrinology
  • Surgical Research

Background

  • Pancreatic ductal adenocarcinoma (PDAC) surgery can lead to postpancreatectomy diabetes mellitus (PPTDM).
  • Identifying risk factors for PPTDM and its impact on survival is crucial for patient management.

Purpose Of The Study

  • To investigate risk factors associated with PPTDM in PDAC patients.
  • To evaluate the diagnostic value of perioperative fasting blood glucose (FBG) levels for long-term survival after pancreatic surgery.

Main Methods

  • A cohort of 509 PDAC patients undergoing resection were analyzed.
  • Patients were stratified into PPTDM and control groups.
  • Univariate/multivariate logistic regression, ROC curve analysis, and Kaplan-Meier methods were used to assess risk factors and FBG levels' impact on survival.

Main Results

  • PPTDM patients had higher BMI, jaundice, tumor diameter, TNM stage, and distal pancreatectomy rates.
  • Preoperative and postoperative FBG levels were significantly higher in the PPTDM group.
  • Combined preoperative and postoperative FBG levels demonstrated the highest diagnostic efficacy for predicting long-term survival (AUC=0.745).

Conclusions

  • PPTDM is a significant complication impacting pancreatic cancer prognosis.
  • Perioperative FBG levels are valuable indicators for long-term survival prediction.
  • Early management of perioperative FBG may mitigate PPTDM risk and improve outcomes.

Keywords:

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