Do firefighters constitute a high-risk population for genotoxicity (DNA damage)? A systematic review

Firefighters regularly undertake high-risk operations in diverse environments, exposing them to extreme temperatures and hazardous pollutants resulting from combustion. For this reason, this systematic review aims to evaluate the potential genotoxicity associated with occupational exposure specific to firefighters. Methodologically, the review included 12 studies assessing genetic damage in firefighters. A thorough quality assessment was performed to account for potential confounding factors, and almost all studies were deemed as either strong or moderate (except for one), ensuring the reliability of the key findings. Likewise, more than half of the articles reviewed (7 out of 12) reported elevated levels of genotoxicity in firefighters, as evidenced by various assays employed in the studies. Taken together, the findings highlight the critical need for implementing biomonitoring strategies for early detection of genotoxicity among firefighters, emphasizing the necessity for further research in this occupational context.