Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.7K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

3.4K
The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
3.4K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

10.3K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
10.3K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.4K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

2.0K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.0K
Abnormal Proliferation02:23

Abnormal Proliferation

4.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Exploratory Pilot Study of Coagulation- and Fibrinolysis-Related Proteins in Unexplained Infertility.

International journal of molecular sciences·2026
Same author

Curcumin as a Multifaceted Epigenetic Modulator With a Disease-Oriented Perspective.

Phytotherapy research : PTR·2026
Same author

Therapeutic Effects of Glucagon-like Peptide-1 Receptor Agonists in Non-Alcoholic Fatty Liver Disease: A Systematic Review.

International journal of molecular sciences·2026
Same author

BCG vaccination as an adjunctive strategy in type 1 diabetes: A systematic review of immunometabolic effects and clinical evidence.

Pathology, research and practice·2026
Same author

Mechanistic interactions between curcumin and statins: pharmacological convergence and therapeutic implications.

Molecular biology reports·2026
Same author

Exploring the Potential of Calebin-A in Targeting Obesity-Related Genes and Pathways.

Journal of cellular and molecular medicine·2026

Related Experiment Video

Updated: May 27, 2025

Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module
10:39

Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module

Published on: June 18, 2015

13.1K

Targeting mTOR with curcumin: therapeutic implications for complex diseases.

Danial Khayatan1,2, Seyed Mehrad Razavi1,2, Zahra Najafi Arab1,2

  • 1Department of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Inflammopharmacology
|February 16, 2025
PubMed
Summary

Curcumin may help treat complex diseases by regulating the mammalian target of rapamycin (mTOR) pathway. This natural compound shows promise in managing conditions linked to mTOR signaling, offering therapeutic benefits.

Keywords:
Curcuma longaInflammatory Signaling PathwaysMammalian target of rapamycin (mTOR)

More Related Videos

A Semi-Quantitative Drug Affinity Responsive Target Stability DARTS assay for studying Rapamycin/mTOR interaction
00:05

A Semi-Quantitative Drug Affinity Responsive Target Stability DARTS assay for studying Rapamycin/mTOR interaction

Published on: August 27, 2019

16.1K
Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells
12:55

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

Published on: October 10, 2017

8.9K

Related Experiment Videos

Last Updated: May 27, 2025

Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module
10:39

Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module

Published on: June 18, 2015

13.1K
A Semi-Quantitative Drug Affinity Responsive Target Stability DARTS assay for studying Rapamycin/mTOR interaction
00:05

A Semi-Quantitative Drug Affinity Responsive Target Stability DARTS assay for studying Rapamycin/mTOR interaction

Published on: August 27, 2019

16.1K
Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells
12:55

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

Published on: October 10, 2017

8.9K

Area of Science:

  • Cellular Biology
  • Biochemistry
  • Pharmacology

Background:

  • The mammalian target of rapamycin (mTOR) pathway is vital for cellular processes like autophagy, proliferation, and apoptosis.
  • Dysregulation of mTOR signaling is implicated in diseases such as cancer, neurodegeneration, obesity, and diabetes.
  • mTOR interacts with numerous other pathways (e.g., NF-κB, Akt, MAPK) influencing inflammation, cell survival, and oxidative stress.

Purpose of the Study:

  • To review the potential of curcumin in modulating the mTOR signaling pathway.
  • To explore the therapeutic implications of curcumin's effects on mTOR for various diseases.

Main Methods:

  • Literature review of studies investigating curcumin and mTOR signaling.
  • Analysis of preclinical and clinical data on curcumin's biological activities.
  • Synthesis of information on the molecular mechanisms of curcumin's interaction with mTOR.

Main Results:

  • Curcumin exhibits regulatory effects on the mTOR pathway.
  • Evidence suggests curcumin can influence autophagy and apoptosis.
  • The compound's interaction with mTOR is linked to its potential in managing metabolic, neurological, and cardiovascular conditions.

Conclusions:

  • Curcumin represents a promising agent for modulating mTOR signaling.
  • Targeting mTOR with curcumin may offer a novel therapeutic strategy for complex diseases.
  • Further research into curcumin's role in mTOR modulation could lead to new preventative and treatment approaches.