Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatiotemporal dynamics of tau extent and load increase in Alzheimer's disease across four longitudinal cohorts.

Nature aging·2026
Same author

Oligodendrocyte Piezo2 is a regulator of age-dependent myelin integrity and dysregulated in multiple sclerosis.

Communications biology·2026
Same author

Multiscale imaging reveals compartment-specific mechanobiology of the osteochondral unit in knee osteoarthritis.

Acta biomaterialia·2026
Same author

Neuroglial P2Y<sub>1</sub> receptor signalling differentially contributes to inflammatory neurodegeneration.

Journal of neuroinflammation·2026
Same author

Tau extent outperforms tau load as a predictor of neurodegeneration in Alzheimer's disease.

Molecular neurodegeneration·2026
Same author

[Primary total knee arthroplasty in geriatric patients with tibial plateau fractures].

Unfallchirurgie (Heidelberg, Germany)·2026

Related Experiment Video

Updated: Jun 13, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
08:47

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

23.6K

Biphasic bone loss in experimental autoimmune encephalomyelitis.

Constantin Schmidt1, Marcel S Woo2, Assil-Ramin Alimy3

  • 1Institute of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|February 16, 2025
PubMed
Summary

Multiple sclerosis (MS) causes bone loss by affecting bone remodeling. This study reveals a biphasic mechanism in mice, offering insights for treating osteoporosis in people with MS.

Keywords:
CXCL13cytokineimaginginflammationmouse modelmultiple sclerosisosteoporosis

More Related Videos

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
06:19

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

3.4K
Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

1.3K

Related Experiment Videos

Last Updated: Jun 13, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
08:47

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

23.6K
Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
06:19

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

3.4K
Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

1.3K

Area of Science:

  • Neuroimmunology
  • Bone Biology
  • Autoimmune Diseases

Background:

  • Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disorder.
  • MS impacts peripheral immunity, but effects on other organs like bone are understudied.
  • People with MS (pwMS) exhibit impaired bone health and higher fracture risks.

Purpose of the Study:

  • Investigate bone microarchitecture and remodeling mechanisms in pwMS and an MS mouse model (EAE).
  • Elucidate the cellular and molecular drivers of bone loss in MS.
  • Identify stage-dependent mechanisms of bone loss in EAE.

Main Methods:

  • Analysis of bone microarchitecture in pwMS and EAE mice.
  • Assessment of cellular and molecular changes in bone remodeling.
  • Investigation of the role of CXCL13/CXCR5 signaling in EAE bone loss.

Main Results:

  • Both pwMS and EAE mice showed reduced bone mineral density (trabecular and cortical bone loss).
  • EAE mice exhibited biphasic bone loss: decreased bone formation (osteocyte apoptosis) in acute EAE, and increased resorption in chronic EAE.
  • Increased CXCL13/CXCR5 signaling correlated with bone loss in chronic EAE.

Conclusions:

  • Bone loss in MS is linked to stage-dependent alterations in bone remodeling.
  • CXCL13/CXCR5 signaling is implicated in the bone loss observed in the chronic phase of EAE.
  • Understanding these mechanisms may inform novel osteoporosis treatments for pwMS.