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Related Experiment Video

Updated: May 27, 2025

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CT-guided transthoracic needle biopsy: How we do it.

Maurizio Balbi1, Luisella Righi2, Noemi Cristina Culasso1

  • 1Radiology Unit, San Luigi Gonzaga Hospital, Department of Oncology, University of Turin, Regione Gonzole 10, 10043 Orbassano (TO), Italy.

European Journal of Radiology
|February 16, 2025
PubMed
Summary

This guide details CT-guided transthoracic needle biopsy for diagnosing lung lesions. It offers practical techniques for maximizing tissue yield and minimizing complications, crucial for accurate cancer diagnosis and molecular analysis.

Keywords:
Biopsy, needleComputed tomographyLung neoplasmsMultidisciplinary care teamPathology, molecular

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Area of Science:

  • Pulmonology
  • Radiology
  • Oncology

Background:

  • CT-guided transthoracic needle biopsy is standard for pulmonary lesion diagnosis.
  • Varied practices exist due to differing resources and operator experience.
  • Gaps remain in large controlled trial data for procedural aspects.

Purpose of the Study:

  • To provide a comprehensive summary of CT-guided transthoracic needle biopsy.
  • To standardize best practices for tissue acquisition and complication management.
  • To guide proper specimen handling for molecular analyses in lung cancer.

Main Methods:

  • Review of clinical practice, research findings, and interdisciplinary collaboration.
  • Description of essential procedural steps from patient selection to onsite evaluation.
  • Emphasis on techniques to optimize tissue retrieval and minimize risks.

Main Results:

  • Standardized approach to CT-guided transthoracic needle biopsy.
  • Techniques for maximizing diagnostic yield and patient safety.
  • Guidelines for specimen handling for molecular testing.

Conclusions:

  • CT-guided transthoracic needle biopsy requires standardized techniques for optimal outcomes.
  • Proper specimen handling is vital for molecular diagnostics in lung cancer.
  • This article serves as a practical resource for clinicians performing the procedure.