Mapping Structural Neuroimaging Trajectories in Bipolar Disorder: Neurobiological and Clinical Implications

Neuroimaging is a powerful noninvasive method for studying brain alterations in bipolar disorder (BD). To date, most neuroimaging studies of BD have included smaller cross-sectional samples reporting case versus control comparisons, revealing small to moderate effect sizes. In this narrative review, we discuss the current state of structural neuroimaging studies using magnetic resonance imaging, which inform our understanding of altered brain trajectories in BD across the lifespan. Alternative methodologies such as those that model patient deviations from age-specific norms are discussed, which may help derive new markers of BD pathophysiology. We discuss evidence from neuroimaging genetics and transcriptomics studies, which attempt to bridge the gap between macroscale brain variations and underlying microscale neurodevelopmental mechanisms. We conclude with a look toward the future and how ambitious investments in longitudinal, deeply phenotyped, population-based cohorts can improve modeling of complex clinical factors and provide more clinically actionable brain markers for BD.