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Updated: May 27, 2025

Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish
Published on: July 16, 2012
Design, synthesis and biological evaluation of Streptazolin analogs as anti-inflammatory agents
Shan Lu1, Zhuang Li1, Peng Jiang2
1School of Pharmacy, Jiangsu University, Zhenjiang 212013, China.
Abstract:
A plant endophytic actinomycete Streptomyces sp. JS39-4 was isolated from the root of water spinach (Ipomoea aquatica Forsk.). Its main secondary metabolite streptazolin (1) was purified in a high yield under the optimized cultural condition. Sixteen analogs of streptazolin with modification at C-5 were synthesized. Among them, compound 2e exhibits the most potent anti-inflammatory activity in LPS-induced RAW 264.7 mouse macrophages. The current research provides the first report on the anti-inflammatory activity of streptazolin analogs.
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