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Updated: May 27, 2025
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
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Coeliac disease masquerading as macroamylasaemia.
Bashayer Al-Rufayi1, Abdulmalik M Alsabban2, Abbas A Zagnoon1
1Gastroenterology Section, Department of Medicine, Prince Mohammad Bin Abdulaziz Hospital, Ministry of National Guard, Madinah, Saudi Arabia.
BMJ Case Reports
|February 16, 2025
Summary
Macroamylasemia, a condition with high amylase levels, can be linked to coeliac disease. In a rare case, coeliac disease presented as pancreatitis due to macroamylasemia.
Area of Science:
- Biochemistry
- Gastroenterology
- Clinical Medicine
Background:
- Macroamylasemia (MA) is a biochemical disorder defined by elevated serum amylase activity.
- It arises from a macromolecular complex of amylase and a serum component, hindering renal excretion.
- Coeliac disease (CD) and MA have been rarely reported together, with inconsistent dietary treatment outcomes.
Purpose of the Study:
- To report a unique case of coeliac disease presenting as recurrent pancreatitis.
- To highlight the role of macroamylasemia in this presentation.
Main Methods:
- Case report detailing clinical presentation, diagnostic workup, and management.
- Biochemical analysis for serum amylase and associated complex.
- Diagnostic confirmation of coeliac disease.
Main Results:
- A case of coeliac disease was identified, mimicking recurrent pancreatitis.
- Macroamylasemia was present and associated with the coeliac disease presentation.
- The interplay between MA and CD in this clinical scenario was observed.
Conclusions:
- Macroamylasemia can complicate the diagnosis of coeliac disease.
- Coeliac disease should be considered in patients with unexplained pancreatitis and MA.
- This case underscores the diverse clinical manifestations of coeliac disease.
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