[Guidelines for medical nutritional therapy in adult sepsis patients (2025 edition)]

Although medical nutritional therapy affects the prognosis of sepsis patients, there is controversy over its clinical implementation process. To further standardize the medical nutrition therapy of sepsis patients, the Chinese Society of Parenteral and Enteral Nutrition (CSPEN) organized more than 50 experts from critical care medicine, clinical nutrition, evidence based medicine and statistics to formulate the guidelines. The guideline was based on grading of recommendations, development and evaluations (GRADE) standards and procedures, through systematic retrieval and evidence sorting, and combined with the practical experience of clinical experts. The guidelines provide recommendations on nutritional risk screening in medical nutrition therapy for sepsis patients, early medical nutrition therapy (enteral nutrition, parenteral nutrition, energy intake, optimal target for protein delivery), enteral nutrition infusion mode, traditional Chinese medicine and protecting intestinal function, nutritional supplements (vitamin, glutamine, omega-3 fatty acids, selenium), probiotics, and the use of proton pump inhibitors. Ultimately, 14 questions and 14 recommendations were formed in order to improve the medical nutrition therapy process for sepsis patients.