Related Experiment Video
Updated: May 27, 2025

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study
Published on: January 31, 2014
Description of chemical systems by means of response functions
E Franco1, B Kepka2, J J L Velázquez3
1Institute for Applied Mathematics, University of Bonn, Endenicher Allee 60, 53115, Bonn, Germany. franco@iam.uni-bonn.de.
Abstract:
In this paper we introduce a formalism that allows to describe the response of a part of a biochemical system in terms of renewal equations. In particular, we examine under which conditions the interactions between the different parts of a chemical system, described by means of linear ODEs, can be represented in terms of renewal equations. We show also how to apply the formalism developed in this paper to some particular types of linear and non-linear ODEs, modelling some biochemical systems of interest in biology (for instance, some time-dependent versions of the classical Hopfield model of kinetic proofreading). We also analyse some of the properties of the renewal equations that we are interested in, as the long-time behaviour of their solution. Furthermore, we prove that the kernels characterising the renewal equations derived by biochemical system with reactions that satisfy the detail balance condition belong to the class of completely monotone functions.
Related Concept Videos
Classification of Systems-I
Homogeneity dictates that if an input x(t) is multiplied by a constant c, the output y(t) is multiplied by the same constant. Mathematically, this is expressed as:
First Order Systems
When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
Transient and Steady-state Response
These test signals are integral in designing control systems to exhibit two key performance aspects: transient response and steady-state...
Classification of Systems-II
Feedback control systems
Linear feedback systems are theoretical models that simplify analysis and design. These systems operate under the principle that their output is directly proportional to their input within certain ranges. For instance, an amplifier in a control system behaves linearly as long as the input signal remains within a specific range. However, most physical systems exhibit inherent nonlinearity...
Mechanical Systems

