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Updated: May 27, 2025

A High Output Method to Isolate Cerebral Pericytes from Mouse
Published on: January 14, 2020
The intriguing perineurial cells - an updated overview of their origin, structure, functions and implication in
Anne Marie Constantin1, Adina Bianca Boşca, Carmen Bianca Crivii
1Discipline of Histology, Department of Morpho-functional Sciences, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; biancabosca@yahoo.com.
Abstract:
The paper overviews the uniquely intricate and distinct perineurium that envelops nerve fibers in bundles. It consists of perineurial cells (PCs), connective tissue, and blood vessels. The perineurium creates a microenvironment for efficient signal transmission, protects and maintains neuronal structure and function, and facilitates neuronal repair. PCs are a unique type of myofibroblasts essential for maintaining nerve homeostasis. They act as an effective blood-nerve barrier (BNB), protecting against toxins, infections, and mechanical trauma. Despite their crucial function, the origin, ultrastructure, molecular structure, and functional roles of PCs remain a mystery, making them a fascinating area of study.
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