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Published on: July 19, 2024
The burden of cancer in metabolic dysfunction-associated steatotic liver disease
Bianca Florentina Pîrvu1, Diana Clenciu, Luiza Andreea Beldie
1Department of General Surgery, Department of Diabetes, Nutrition and Metabolic Diseases, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania; doctortts@yahoo.com; adina.mitrea@umfcv.ro.
Abstract:
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide and has become a major public health problem. MASLD frequently progresses to cirrhosis and hepatocellular carcinoma, but recent studies also show a frequent association with extrahepatic cancers. One of the mechanisms involved in both locations is insulin resistance and hyperinsulinemia. The aim of this narrative review was to present the main etiopathogenic mechanisms involved in cancer development in patients with MASLD.
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