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Updated: Jun 15, 2025

A Protocol to Evaluate and Quantify Retinal Pigmented Epithelium Pathologies in Mouse Models of Age-Related Macular Degeneration
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Activated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD-Like Pathology

Olivia Chowdhury1, Sridhar Bammidi1, Pooja Gautam1

  • 1Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Aging Cell
|February 17, 2025
PubMed
Abstract

Keywords:
RPEepithelial–mesenchymal transitionmLST8mTOR complex 1mTOR complex 2metabolic/mitochondrial changes

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