Related Experiment Video
Updated: May 27, 2025
03:05
Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
Published on: February 16, 2024
956
Predictive Model for Hypoglycaemia Risk in Type 2 Diabetes Mellitus Patients During the Peri-Colonoscopy Period: A
Haiyan Yang1, Linlin Zhang1, Huiling Liu1
1Department of Endocrinology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, People's Republic of China.
Journal of Advanced Nursing
|February 17, 2025
Summary
This study developed a predictive model to identify type 2 diabetes patients at risk for low blood sugar during colonoscopy. The model helps nurses implement personalized strategies to prevent complications.
Area of Science:
- Endocrinology
- Gastroenterology
- Clinical Research
Background:
- Hypoglycaemia is a significant risk for patients with type 2 diabetes mellitus (T2DM) undergoing colonoscopy.
- Effective risk stratification is crucial for patient safety and optimal procedural outcomes.
Purpose of the Study:
- To identify factors influencing hypoglycaemia in T2DM patients during colonoscopy.
- To develop and validate a predictive model for peri-colonoscopy hypoglycaemia risk.
Main Methods:
- Retrospective cohort study of 598 T2DM patients undergoing colonoscopy.
- Data split into developmental (70%) and validation (30%) cohorts.
- Multivariate logistic regression used to identify predictors and build the model.
Main Results:
- 18.7% of patients experienced peri-colonoscopy hypoglycaemia.
- Key predictors identified: insulin, SGLT2 inhibitors, fasting post-colonoscopy, fasting C-peptide, and eGFR.
- Model demonstrated good predictive performance (AUC 0.78-0.82).
Conclusions:
- A validated predictive model for peri-colonoscopy hypoglycaemia in T2DM patients was successfully developed.
- The model enables early identification of high-risk patients for targeted interventions.
- Clinical nurses can utilize this tool for personalized blood glucose monitoring and preventive strategies.
Related Concept Videos
01:15Hypoglycemia and Glucagon
149
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
149
01:22Diabetes Mellitus: Type 2 and Gestational
2.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.1K
01:15Diabetes: Symptoms, Diagnosis, and Complications
498
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
498
01:25Endoscopic Procedures II: Colonoscopy
48
The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
48
01:22Diabetes Mellitus: Overview and Type I Subtype
2.4K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.4K
01:16Insulin: Dosing Regimen and Adverse Effects
139
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
139