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Related Experiment Videos

The daytime breath hydrogen profile: technical aspects and normal pattern.

C M Kneepkens, R J Vonk, C M Bijleveld

    Clinica Chimica Acta; International Journal of Clinical Chemistry
    |April 30, 1985
    PubMed
    Summary
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    A new breath sampling method allows for easy at-home hydrogen estimations. This technique helps identify normal daytime breath patterns and may aid in diagnosing carbohydrate malabsorption in children.

    Area of Science:

    • Gastroenterology
    • Clinical Chemistry

    Background:

    • Breath hydrogen measurements are valuable for diagnosing conditions like carbohydrate malabsorption.
    • Existing methods can be cumbersome for routine or at-home use.

    Purpose of the Study:

    • To describe and validate a novel, simplified breath sampling method for hydrogen analysis.
    • To establish a normal daytime breath hydrogen profile in children.
    • To assess the utility of this method in identifying potential carbohydrate malabsorption.

    Main Methods:

    • A 10-ml syringe with a side hole was used for end-expiratory air sampling.
    • Samples were transferred to vacuum tubes for storage and mailing.
    • Hydrogen concentration was determined using gas chromatography on 0.4 ml of sampled air.

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  • Fourteen children provided breath samples every 30 minutes over a full day, recording diet and activity.

    • Main Results:

    • A distinct normal daytime breath hydrogen profile was observed, with low morning and increased evening values in half of the children.
    • Significant differences in breath hydrogen patterns were noted compared to children with diagnosed carbohydrate malabsorption.
    • The method proved easy to perform and suitable for home use.

    Conclusions:

    • The described breath sampling technique is practical for both clinical and home settings.
    • The established daytime breath hydrogen profile provides a reference for normal physiological patterns.
    • This accessible method offers valuable supplementary data for investigating suspected carbohydrate malabsorption in pediatric patients.