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Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) in Patients With Acromegaly in Colombia
Alin Abreu Lomba1, Juan Manuel Montoya Ospina2, David Alexander Vernaza Trujillo3,2
1Endocrinology, Imbanaco Clinic, Cali, COL.
Cureus
|February 17, 2025
Summary
Sleep apnea/hypopnea syndrome (SAHS) affects over half of acromegaly patients, linked to longer disease duration and higher IGF-1 levels. Early diagnosis and treatment are crucial for managing this common comorbidity.
Area of Science:
- Endocrinology
- Sleep Medicine
- Cardiovascular Disease
Background:
- Acromegaly, a rare disorder from excess growth hormone (GH), affects ~5 per million annually.
- Sleep apnea/hypopnea syndrome (SAHS) impacts up to 80% of acromegaly patients.
- SAHS is an independent risk factor for cardiovascular disease.
Purpose of the Study:
- To determine the prevalence of SAHS in Colombian acromegaly patients.
- To identify factors associated with SAHS in this population.
Main Methods:
- Observational, retrospective cohort study using the National Registry of Patients with Acromegaly (RAPACO).
- Inclusion criterion: baseline polysomnography (PSG).
- 163 patients evaluated.
Main Results:
- 54.6% of patients (89/163) were diagnosed with SAHS.
- OSAHS patients had higher BMI, longer disease duration, and elevated IGF-1 and GH levels (p=0.006, p=0.027).
- Multivariate analysis linked disease duration and IGF-1 levels to SAHS.
Conclusions:
- SAHS is a highly prevalent comorbidity in acromegaly patients.
- Hormonal factors, particularly elevated IGF-1 and GH, are critical in SAHS pathogenesis.
- Routine PSG screening for SAHS in acromegaly patients is recommended.
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