Cariprazine for Clozapine-Induced Urinary Incontinence in Treatment-Resistant Depression: A Case Report

Urinary incontinence (UI) is an adverse effect associated with clozapine treatment. Several management options are available, including adjuvant medication. We describe the case of a woman in her 50s with a history of major depressive disorder and a current severe depressive episode with psychotic symptoms. The case is discussed, and a review of the relevant literature is presented, examining the use of cariprazine in the management of clozapine-induced UI. Cariprazine was initiated as a first-line treatment, followed by clozapine several months later. Following a reduction in the dose of cariprazine, the patient developed UI. Physical examination was unremarkable, and laboratory investigations were normal. No additional interventions were required. No other medication was altered, and upon reintroduction of cariprazine, the patient's UI improved significantly. Although a single case is inadequate for establishing definitive conclusions, this case report indicates the need for further investigation into the potential of cariprazine in addressing clozapine-induced UI.