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  1. Home
  3. Covid-19 Associated Liver Injury: An Updated Review On The Mechanisms And Management Of Risk Groups.
  1. Home
  3. Covid-19 Associated Liver Injury: An Updated Review On The Mechanisms And Management Of Risk Groups.

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COVID-19 associated liver injury: An updated review on the mechanisms and management of risk groups.

Yue Shi1,2, Mina Wang2,3, Liqun Wu1

  • 1Second Clinical Medical College, Beijing University of Chinese Medicine, Beijing, China.

Liver Research
|February 17, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Coronavirus disease 2019 (COVID-19) can cause liver injury through direct viral effects or indirect inflammation. Patients with pre-existing liver conditions face higher risks, necessitating vigilant monitoring and early supportive care.

Keywords:
Coronavirus disease 2019 (COVID-19)Liver injuryManagementRisk groupsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Treatments

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Area of Science:

  • Hepatology
  • Infectious Diseases
  • Internal Medicine

Background:

  • Coronavirus disease 2019 (COVID-19) is linked to diverse liver injury cases globally.
  • The precise prevalence, mechanisms, and clinical outcomes of COVID-19-induced liver injury (CILI) in vulnerable populations remain unclear.

Purpose of the Study:

  • To review and synthesize current knowledge on CILI in various at-risk groups.
  • To define clinical characteristics, diagnostic parameters, and prognostic indicators of CILI.
  • To explore potential therapeutic strategies for managing CILI.

Main Methods:

  • Systematic review of existing studies on CILI.
  • Analysis of clinical data, laboratory parameters, and patient outcomes.
  • Identification of correlations between disease severity and specific indicators.

Main Results:

  • CILI can result from direct viral impact, systemic inflammation, hypoxia, and drug toxicity.
  • Individuals with underlying liver disease, cardiopulmonary issues, metabolic disorders, and specific life stages are at increased risk.
  • Key clinical and laboratory findings associated with CILI severity were identified.

Conclusions:

  • Understanding CILI in diverse populations is crucial for effective management.
  • Close monitoring of liver function in at-risk patients is essential for early intervention.
  • Proactive supportive care can mitigate adverse outcomes associated with CILI.