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Using a Two-Steps Clustering and PCA Analysis for Stratified Chronic Non-Cancer Pain Care: A Retrospective
Ana M Peiró1,2, Jordi Barrachina1, Mónica Escorial1
1Neuropharmacology Applied to Pain (NED), Clinical Pharmacology Unit, Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, 03010, Spain.
Journal of Pain Research
|February 17, 2025
Summary
This study identified six patient clusters for chronic non-cancer pain (CNCP) to guide stratified care. Findings highlight factors like age and medication impacting quality of life, aiding personalized pain management.
Area of Science:
- Pain Medicine
- Health Services Research
- Data Science in Healthcare
Background:
- Chronic non-cancer pain (CNCP) affects many individuals, straining healthcare resources.
- Effective management requires stratified care tailored to patient needs.
- Current approaches may lack detailed patient phenotyping for optimal treatment matching.
Purpose of the Study:
- To characterize chronic non-cancer pain (CNCP) patient states using unsupervised cluster analysis.
- To identify distinct patient groups requiring different pain intervention strategies.
- To inform clinical recommendations for stratified pain care.
Main Methods:
- Analysis of a real-world ambulatory CNCP cohort (n=418) using patient-reported data.
- Clustering based on pain intensity/relief, quality of life, adverse events, and ED visits.
- Principal component analysis to define clusters and intervention requirements; retrospective validation (n=120).
Main Results:
- Six distinct patient clusters were identified, indicating different monitoring and clinical status.
- Older age (>65), retirement/medical leave, opioid/anxiolytic use significantly impacted quality of life.
- No significant sex differences were observed in the impact on daily quality of life.
Conclusions:
- Identified clusters can aid in screening patients, especially where physical examination access is limited.
- This data-driven stratification supports personalized pain management strategies.
- Further analyses are needed to confirm the replicability and clinical utility of this stratified care approach.
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