Acetyltransferase in cardiovascular disease and aging

Area of Science:

• Biochemistry
• Molecular Biology
• Gerontology

Background:

• Acetyltransferases catalyze acetylation, a vital post-translational modification.
• Dysfunctional acetyltransferases are linked to congenital disorders and aging-related diseases.
• Cardiovascular diseases are major causes of mortality, exacerbated by metabolic syndrome and aging.

Purpose of the Study:

• To review the roles and relevance of acetyltransferases in health and aging.
• To discuss acetyltransferase-related pathologies, focusing on cardiovascular disease.
• To explore therapeutic applications of acetyltransferases for healthy aging.

Main Methods:

• Literature review of acetyltransferase functions and pathologies.
• Classification of acetyltransferases based on domain structure.
• Analysis of recent research on acetyltransferases in aging and disease.

Main Results:

• Acetyltransferases link lifestyle, cardiometabolic disease, and aging.
• They play essential roles in cell proliferation, DNA damage response, mitochondrial function, inflammation, and senescence.
• Recent research emphasizes their importance beyond the well-studied sirtuins.

Conclusions:

• Acetyltransferases are critical regulators of healthspan and lifespan.
• Understanding their mechanisms offers therapeutic targets for age-related diseases, especially cardiovascular conditions.
• Targeting acetyltransferases may promote healthy aging and mitigate disease burden.