Demonstration of femtosecond laser induced refractive index change in silk-fibroin hydrogels

We present induced refractive index changes in biocompatible silk fibroin hydrogels using two different femtosecond laser systems: one using 400 nm at 80 MHz and the other employing 517 nm at 8.3 MHz. Both modalities produced significant index changes, demonstrating the potential to create custom refractive correctors. Additionally, the biocompatibility and environmentally friendly properties of silk-fibroin make it an ideal platform for developing new types of intraocular implants that incorporate tunable refractive corrections.