Related Experiment Video
Updated: May 13, 2026
17:13
Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET
Published on: April 28, 2013
16.9K
Delayed graft function after renal transplantation
Darijus Skaudickas1, Povilas Lenčiauskas2, Augustas Skaudickas2
1Lithuania Medical Academy, Lithuanian University of Health Sciences, Eiveniu 2, 50161, Kaunas, Lithuania.
Open Medicine (Warsaw, Poland)
|February 17, 2025
Summary
Delayed graft function (DGF) in kidney transplants can be prolonged, even beyond one month. This case highlights that decisions about removing a non-functioning kidney graft should not be rushed, as recovery is possible.
Area of Science:
- Nephrology
- Transplantation immunology
Background:
- Delayed graft function (DGF) is a frequent complication post-kidney transplant, especially with extended criteria donors.
- The incidence of DGF ranges from 21-31% in these high-risk transplants.
Observation:
- A 47-year-old patient with diabetic nephropathy experienced prolonged DGF after receiving a marginal deceased donor kidney.
- Graft function remained impaired for 4 weeks, with anuria lasting 29 days before recovery.
Findings:
- The patient had multiple DGF risk factors: diabetes, pre-transplant dialysis, and moderate immunologic mismatch.
- Marginal graft quality likely contributed to ischemia-reperfusion injury and glycocalyx damage, but the exact cause of prolonged DGF is unclear.
- Literature review revealed limited cases of DGF exceeding one month.
Implications:
- This case underscores the lack of data on factors causing extended DGF.
- It suggests that non-functioning kidney grafts should not be removed prematurely.
- Further research is needed to understand prolonged DGF and optimize transplant outcomes.
Related Concept Videos
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
01:26Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
01:16Kidney Transplant III: Nursing Management
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
01:29Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...