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Temporal and spatial characterization of keratinocytes supporting orf virus replication

Byung-Joon Seung1, Sushil Khatiwada1, Daniel L Rock1

  • 1Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, United States.

Frontiers in Cellular and Infection Microbiology
|February 17, 2025
PubMed
Summary

Orf virus (ORFV) replicates in specific differentiating skin cells, not proliferating ones, after wound-induced skin damage. This finding clarifies ORFV tropism and delayed replication in sheep and goats.

Keywords:
full thickness wound skin modelin situ hybridization (ISH)keratinocytesorf viruspathogenesissheep

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