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Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
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Green coffee infusion: An endodontic elixir.
Tanya Chondamma1, Ponappa Muckatira Cariappa1, K C Ponnappa1
1Department of Conservative Dentistry and Endodontics, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India.
Journal of Conservative Dentistry and Endodontics
|February 17, 2025
Summary
Coffee extracts, particularly from Robusta varieties, show significant antimicrobial efficacy for root canal irrigation. These natural compounds offer a promising alternative to traditional irrigants like sodium hypochlorite (NaOCl) for improved endodontic therapy.
Area of Science:
- Endodontics
- Microbiology
- Phytochemistry
Background:
- Traditional root canal irrigants like sodium hypochlorite (NaOCl) have limitations including cytotoxicity and incomplete microbial eradication.
- Phytochemicals from plants, such as coffee, possess antimicrobial properties and are explored as alternatives.
Purpose of the Study:
- To evaluate the efficacy of intracanal irrigants derived from locally cultivated *Coffea arabica* and *Coffea canephora* (Robusta) varieties.
- To assess the antimicrobial attributes of coffee extracts as potential endodontic irrigants.
Main Methods:
- Seventy extracted human single-rooted teeth were used.
- Coffee extracts were prepared via decoction; minimum inhibitory concentrations (MICs) were determined using microbroth dilution assays.
- Microbial growth was quantitatively assessed over time.
Main Results:
- Green Robusta extracts demonstrated antimicrobial effectiveness at 25% and 12.5% concentrations.
- All coffee extract groups significantly reduced microbial counts compared to the negative control.
- The 12.5% green Robusta extract showed sustained antimicrobial efficacy.
Conclusions:
- Coffee extracts, especially from Robusta, present a novel approach for endodontic therapy.
- These findings suggest coffee extracts as a potentially effective and safer alternative to NaOCl.
- Utilization of coffee extracts may enhance dental health outcomes in endodontic treatments.

