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Gold Nanoraspberries for Surface-Enhanced Raman Scattering: Synthesis, Optimization, and Characterization.

Megha Mehta1, William Skinner1, Benjamin Gardner1

  • 1Department of Physics and Astronomy, University of Exeter, Exeter EX4 4QL, U.K.

ACS Omega
|February 17, 2025
PubMed
Summary
This summary is machine-generated.

Gold nanoraspberries (AuNRB) and gold nanospheres (AuNS) were synthesized and compared for their SERS performance. AuNRB demonstrated superior SERS enhancement with all reporters, especially the clinically approved IR820, indicating potential for in vivo applications.

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Area of Science:

  • Nanotechnology
  • Surface-enhanced Raman scattering (SERS)
  • Biomedical applications

Background:

  • Surface-enhanced Raman scattering (SERS) is a powerful technique for molecular detection, but challenges remain in synthesizing bright gold nanoparticles and selecting optimal Raman labels.
  • Understanding the influence of nanoparticle shape and dispersion stability in physiological media is crucial for developing effective SERS-based diagnostic tools.

Purpose of the Study:

  • To synthesize gold nanoraspberries (AuNRB) and compare their physicochemical properties and SERS performance against gold nanospheres (AuNS).
  • To investigate the dispersion stability of AuNRB and AuNS in various physiological media (ultrapure water, PBS, FBS).
  • To evaluate the SERS and surface-enhanced resonance Raman scattering (SERRS) efficiency using nonresonant (BPE, BPT) and resonant (IR820) reporters.

Main Methods:

  • Synthesis of AuNRB using HEPES buffer at room temperature.
  • Characterization of gold nanoparticles (AuNRB and AuNS) including size, ζ-potential, and UV-vis absorption.
  • Dispersion stability tests in ultrapure water, PBS, and FBS.
  • SERS/SERRS measurements using BPE, BPT, and IR820 as reporter molecules.

Main Results:

  • AuNRB and AuNS exhibited highest stability in ultrapure water; aggregation was observed in PBS.
  • Protein corona formation in FBS led to increased particle size and a shift in surface plasmon absorbance.
  • AuNRB consistently outperformed AuNS in SERS efficiency across all tested reporters.
  • The resonant reporter IR820 yielded a significantly higher SERS signal compared to nonresonant reporters.

Conclusions:

  • AuNRB are a promising nanoparticle platform for enhanced SERS applications due to their superior performance over AuNS.
  • The resonant reporter IR820, being FDA-approved, presents a strong candidate for future in vivo SERS applications.
  • Nanoparticle shape, dispersion stability, and reporter molecule properties significantly impact SERS efficacy.