Synthesis and Characterization of a Strontium-Quercetin Complex and Its In Vitro and In Vivo Potential for...

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Materials Chemistry

Background:

• Existing therapies for bone defects, like strontium ranelate for osteoporosis, present significant side effects.
• Developing safer strontium-based materials is crucial for advancing bone regeneration treatments.

Purpose of the Study:

• To synthesize a new strontium-based complex using quercetin as a platform.
• To evaluate the in vitro and in vivo efficacy of the synthesized strontium-quercetin complex for bone regeneration.

Main Methods:

• Strontium complexation with quercetin.
• Characterization of the complex using Fourier transform infrared spectroscopy, nuclear magnetic resonance, and thermal gravimetric analysis.
• In vitro assessment of osteogenic differentiation and in vivo evaluation using a mouse periapical lesion model.

Main Results:

• The strontium-quercetin complex, [(C15H7O7)Sr2]·6(H2O), was successfully synthesized and characterized.
• The complex significantly enhanced osteogenic differentiation, alkaline phosphatase activity, and extracellular matrix mineralization in vitro.
• In vivo studies demonstrated a reduction in bone defects within 7 days in a mouse periapical lesion model.

Conclusions:

• The synthesized strontium-quercetin complex is a potential candidate for novel bone regeneration therapies.
• This complex offers a safer alternative to existing strontium-based treatments with significant side effects.
• Further research into this complex could lead to improved treatments for bone-related diseases and trauma.