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Correlation between diabetic peripheral neuropathy and thyroid hormone sensitivity in elderly patients with type 2
Si-Jia Fei1, Jing-Yi Luo1, Wei-Hao Wang1
1Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.
Background:
Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes mellitus (T2DM), significantly affecting patients' quality of life and imposing a substantial economic burden. Recent studies have highlighted the role of thyroid hormones in diabetes complications, particularly in elderly patients with T2DM. However, the relationship between thyroid hormone sensitivity and DPN remains unclear.
Aim:
To investigate the correlation between thyroid hormone sensitivity and DPN in elderly patients with T2DM.
Methods:
In a cohort of 256 elderly patients with T2DM, propensity score matching was used to balance age, sex, and diabetes duration. Clinical data were collected to calculate thyroid hormone sensitivity and analyze its correlation with DPN. A random forest model was used to evaluate the diagnostic value of free triiodothyronine/free thyroxine (FT3/FT4) for DPN.
Results:
Patients with DPN had a lower FT3/FT4 ratio [ (0.302 ± 0.053) vs (0.316 ± 0.049), P = 0.040]. Quartile stratification showed decreasing DPN prevalence with higher FT3/FT4 ratios. Spearman's correlation analysis showed that a lower FT3/FT4 ratio was associated with higher glycated hemoglobin, fasting blood glucose, reduced nerve conduction velocity, and electrical skin conductance. Logistic regression indicated a positive relationship between the median FT3/FT4 ratio and bilateral foot electrochemical skin conductance [odds ratio (OR): 1.019; 95%CI: 1.005-1.034; P = 0.007] and sural nerve sensory amplitude (OR: 1.310; 95%CI: 1.008-1.703; P = 0.043). Receiver operating characteristic analysis using a random forest model showed that incorporating FT3/FT4 improved predictive performance for DPN, with an area under the curve of 0.74, sensitivity of 0.79, specificity of 0.64, and accuracy of 0.77.
Conclusion:
In elderly patients with T2DM with euthyroidism, a lower FT3/FT4 ratio is correlated with increased DPN incidence, affecting both large and small nerve fibers. FT3/FT4 is an effective predictor of DPN.
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