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Updated: May 27, 2025

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
DNA methylation in the association between pesticide exposures and type 2 diabetes
Guang-Jun Zheng1, Zheng-Er Fang1, Bi-Ying Zhou1
1Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou 510632, Guangdong Province, China.
Background:
Numerous epidemiological studies have found that pesticide exposure is associated with the incidence of type 2 diabetes (T2D); however, the underlying mechanisms remain unknown. DNA methylation may play a role in this process.
Aim:
To identify the genes associated with pesticide exposure and T2D by reviewing the current literature.
Methods:
We systematically searched PubMed and Embase for relevant studies that examined the association between pesticide exposure and DNA methylation, and studies on DNA methylation and T2D through January 15, 2024.
Results:
We identified six genes (Alu, CABLES1, CDH1, PDX1, PTEN, PTPRN2) related to pesticide exposure and T2D. We also suggested future research directions to better define the role of DNA methylation in the association between pesticide exposure and T2D.
Conclusion:
DNA methylation of specific genes may play a vital role in the association between pesticide exposure and T2D.
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