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PROGNOSTIC VALUES OF LIPID PANEL DATA FOR MACROVASCULAR COMPLICATION DEVELOPMENT IN TYPE 2 DIABETIC PATIENTS WITH
Mariya Marushchak1, Inna Krynytska1, Olena Gashynska2
1Department of Functional and Laboratory Diagnostics, I Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.
Acta Clinica Croatica
|February 17, 2025
Summary
Serum lipid profiles predict macrovascular complications in type 2 diabetes mellitus (T2DM) patients, especially those with thyroid disorders like hypothyroidism (HT) and diffuse non-toxic goiter (DNTG). Specific cut-off values for cholesterol and triglycerides identify high-risk individuals.
Area of Science:
- Endocrinology
- Cardiology
- Clinical Biochemistry
Background:
- Type 2 diabetes mellitus (T2DM) significantly increases the risk of macrovascular complications (MVC).
- Comorbid thyroid dysfunctions, including hypothyroidism (HT) and diffuse non-toxic goiter (DNTG), can further modify cardiovascular risk in T2DM patients.
- The prognostic value of routine lipid panel parameters in T2DM patients with these specific thyroid comorbidities requires detailed evaluation.
Purpose of the Study:
- To assess the predictive capability of serum lipid profiles for the development of MVC in T2DM patients.
- To determine specific lipid cut-off values that indicate an increased risk of MVC in T2DM patients with and without comorbid thyroid dysfunction (HT, DNTG, or both).
- To stratify T2DM patients with thyroid dysfunction based on their risk for MVC development.
Main Methods:
- A cohort of 596 inpatients with T2DM was analyzed.
- Serum lipid parameters including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), non-HDL-cholesterol (non-HDL-C), and remnant cholesterol (RC) were measured.
- Receiver operating characteristic (ROC) analysis was employed to identify prognostically significant lipid values and establish optimal cut-off points for MVC risk stratification.
Main Results:
- Specific prognostic cut-off values for TC, TG, LDL-C, and non-HDL-C were identified for T2DM patients with comorbid HT.
- Distinct cut-off values for TC, TG, LDL-C, and non-HDL-C were established for T2DM patients with comorbid DNTG.
- For T2DM patients with both HT and DNTG, specific cut-off values for TC, TG, LDL-C, non-HDL-C, and RC were determined, indicating their elevated MVC risk.
Conclusions:
- Serum levels of TC, TG, LDL-C, and non-HDL-C are valuable predictors of MVC in T2DM patients with comorbid hypothyroidism.
- Serum lipid profiles, including RC, can effectively stratify T2DM patients with coexisting diffuse non-toxic goiter and hypothyroidism based on their risk for macrovascular complications.
- These findings support the use of lipid panel data for risk assessment and management strategies in T2DM patients with thyroid dysfunction.
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