Related Experiment Video
Updated: May 27, 2025
11:28
A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically
Published on: September 9, 2015
28.9K
Dalbavancin Use in Bone and Joint Infections
Liam P Alderson1, Srivani Sanikommu2, Simon C Mears3
1University of Arkansas for Medical Sciences College of Medicine, Little Rock, AR, USA.
Arthroplasty Today
|February 17, 2025
Summary
Dalbavancin (DAL) effectively treats bone and joint infections, particularly when combined with surgical intervention and hardware removal. This approach significantly reduces the risk of infection recurrence, supporting its use in orthopedic care.
Area of Science:
- Orthopedics
- Infectious Diseases
- Pharmacology
Background:
- Off-label use of Dalbavancin (DAL) for bone and joint infections is increasing due to the convenience of avoiding long-term intravenous access.
- Limited data exists on the efficacy and safety of Dalbavancin in treating these complex infections.
Purpose of the Study:
- To evaluate the effectiveness and safety of Dalbavancin in treating bone and joint infections.
- To identify risk factors for infection recurrence after Dalbavancin treatment.
Main Methods:
- A retrospective, single-center study analyzed data from adult patients treated with Dalbavancin for bone or joint infections between 2019 and 2023.
- Data collected included patient demographics, infection characteristics, prior treatments, and clinical outcomes.
- Statistical analysis was performed to assess risk factors for 1-year infection recurrence.
Main Results:
- Fifty-eight patient encounters were treated with Dalbavancin, primarily for osteomyelitis (81.0%).
- Staphylococcus aureus, including MRSA, was the most common pathogen.
- Hardware removal significantly reduced the risk of recurrence (P = .026), with no recurrence observed in peri-prosthetic joint infection patients.
Conclusions:
- Dalbavancin, when used with surgical debridement and hardware removal, demonstrates effectiveness in treating bone and joint infections.
- Failure to remove infected hardware is a significant risk factor for recurrence.
- Further randomized controlled trials are warranted to confirm Dalbavancin's role in orthopedic infections.
Keywords:
Dalbavancin (DAL)Methicillin-resistant Staphylococcus aureus (MRSA)OsteomyelitisPeri-prosthetic joint infection (PJI)More Related Videos
Related Concept Videos
01:26Pulmonary Tuberculosis IV
128
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
128
01:29Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
01:28Pneumonia IV: Management
287
The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
287
01:22Bone Marrow Sampling and Transplants
275
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
275
01:22Healthcare Associated Infections II: Preventive Measures
2.4K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.4K
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
92
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
92