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Updated: May 27, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
"Naked Nickel"-Catalyzed Heteroaryl-Heteroaryl Suzuki-Miyaura Coupling
Rakan Saeb1, Byeongdo Roh1, Josep Cornella1
1Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470, Mülheim an der Ruhr, Germany.
Abstract:
In this article, we report that the air-stable "naked nickel", [Ni(4-CF3stb)3], is a competent catalyst in the catalytic Suzuki-Miyaura cross-coupling reaction (SMC) between heteroaryl bromides and heteroaromatic boron-based nucleophiles. The catalytic system is characterized by its ability to avoid decomposition or deactivation in the presence of multiple Lewis basic sites. The protocol permits the formation of C‒C bonds between two heteroaryl moieties in the absence of complex exogenous ligands, thus minimizing screening procedures and simplifying reaction setups. This method accommodates combinations of distinct 6-membered heteroaryl bromides and 5- and 6-membered heterocyclic B-based nucleophiles.
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