Implementing Pharmacogenomics Clinical Decision Support: A Comprehensive Tutorial on how to Integrate the Epic...

Area of Science:

• Genomic Medicine
• Clinical Informatics
• Pharmacogenomics

Background:

• Pharmacogenomic (PGx) testing has gained prominence for predicting drug response over the past decade.
• Clinical decision support (CDS) is crucial for integrating PGx results into clinical practice and educating prescribers.
• The Epic Genomics module facilitates the storage of structured genomic data and PGx CDS implementation.

Purpose of the Study:

• To outline the implementation process of the Epic Genomics module at University of Florida Health.
• To identify critical success factors for integrating PGx CDS into electronic health records.

Main Methods:

• The University of Florida Health Precision Medicine Program implemented the Epic Genomics module.
• The tutorial details the specific steps and strategies employed during the deployment.
• Key factors for successful integration were identified through the implementation experience.

Main Results:

• Successful deployment of the Epic Genomics module in early 2022.
• Established a framework for integrating PGx testing into routine clinical workflows.
• Identified best practices for utilizing electronic health record tools for PGx CDS.

Conclusions:

• The implementation of the Epic Genomics module is feasible and beneficial for healthcare institutions.
• Effective PGx CDS integration requires careful planning and execution.
• The University of Florida Health experience provides a valuable model for other institutions seeking to adopt PGx testing.