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Updated: May 27, 2025

Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis
Published on: September 16, 2014
Enantiorecognition in a multi-component environment
Joanna Mazurkiewicz1,2, Ewa Stanek2,3, Pedro Maximiano4
1Faculty of Chemistry, Jagiellonian University, 2 Gronostajowa Str., Krakow 30-387, Poland. agnieszka.kaczor@uj.edu.pl.
Abstract:
We demonstrate that enantiopreference in the binding of S,S over R,R astaxanthin (AXT) to albumin manifests itself only for racemic (but not enantiopure) carotenoids. The observed enantioselectivity is rationalized using chiroptical spectroscopies supported by molecular docking, molecular dynamics and quantum-chemical calculations. These methods offer a plausible explanation for the observed enantiopreference, as they reveal a unique binding mode of the (3S,3'S)-AXT form with the protein in contrast to multiple (random) possibilities for albumin binding with the (3R,3'R)-AXT, and also a higher interaction energy of the latter enantiomer with the protein.
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