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Self-Assembly of Microtubule Tactoids

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Published on: June 23, 2022

Light-Modulated Self-Assembly of Synthetic Nanotubes.

Mahdi Dizani¹, Siddharth Agarwal^1,2, Dino Osmanovic¹

¹Department of Mechanical and Aerospace Engineering, University of California at Los Angeles, Los Angeles, California 90095, United States.

|February 17, 2025

Summary

Researchers developed light-responsive artificial DNA nanotubes that self-assemble upon UV exposure. The speed of nanotube formation is tunable by UV dose, enabling control over biomolecular scaffolds for synthetic cells.

Keywords:

Cytoskeleton DNA nanotechnology Nanotubes Nucleic acids Photoactivation Synthetic cells

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Area of Science:

Biomolecular engineering
Synthetic biology
Nanotechnology

Background:

Stimuli-responsive artificial biomolecular polymers are crucial for advancing living materials and synthetic cells.
Controlling the assembly dynamics of these polymers is essential for their functional applications.

Purpose of the Study:

To demonstrate light-inducible self-assembly of artificial DNA tubular nanostructures.
To engineer DNA tile motifs with UV-responsive domains for controlled nanotube formation.
To couple light-dependent assembly with RNA transcription for multi-stimuli control.

Main Methods:

Design and synthesis of programmable DNA tile motifs incorporating UV-responsive domains.
UV irradiation to trigger nanotube self-assembly in a dose-dependent manner.
Coupling DNA assembly with RNA transcription for integrated physical and biochemical control.

Main Results:

Demonstrated dose-dependent formation of DNA tubular nanostructures in response to UV light.
Showcased tunable nanotube formation speed by adjusting UV irradiation dose.
Illustrated controlled nanotube assembly in confinement, acting as a stimulus-responsive cytoskeletal system.

Conclusions:

Developed novel, UV-activatable DNA tile designs for creating dynamic biomolecular scaffolds.
Established a method for controlling nanotube formation using light and concurrent biochemical stimuli.
Provided a foundation for building rudimentary cytoskeletal systems within minimal synthetic cells.