Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

271
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
271
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

277
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
277
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

303
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
303
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

677
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
677
Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

206
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
206
Prodrugs01:30

Prodrugs

2.4K
Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
Prodrugs help overcome...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High and rapid perfluorooctanoic acid capture by MOF-818 <i>via</i> synergistic adsorption.

Nanoscale·2026
Same author

Binary Living Radical Polymerization of Dual Concurrent ATRP-RAFT.

Polymer science & technology (Washington, D.C.)·2026
Same author

Direct Activation of Follicular Melanocytes by Polymeric Tyrosinase Nanocapsules for Reversing Hair Graying.

ACS nano·2026
Same author

A water-soluble fluorinated metal-organic cage based on paramagnetic copper as an efficient <sup>1</sup>H and <sup>19</sup>F MRI nanoprobe.

Nanoscale·2026
Same author

Discrete Patterned Functional Polymeric Nanostructures via Controlled Biaxial Iterative Synthesis.

Nano letters·2025
Same author

Bimetallic organic cages as precise theranostic nanoplatforms for self-enhanced magnetic resonance imaging and chemodynamic therapy.

Materials horizons·2025

Related Experiment Video

Updated: May 27, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

7.7K

Supramolecular Polymers for Drug Delivery.

Xinyue Zhang1, Jiaxin Zhuo2, Dali Wang1

  • 1School of Chemistry and Chemical Engineering, Zhangjiang Institute for Advanced Study, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, P. R. China.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|February 17, 2025
PubMed
Summary

Supramolecular polymers offer advanced drug delivery solutions due to their reversible nature and responsiveness. These intelligent materials enable precise delivery of small molecules, genes, and proteins for complex disease treatments.

Keywords:
Biomedical applicationsDrug deliveryNon-covalent interactionsSupramolecular polymer

More Related Videos

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

17.3K
Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
08:09

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery

Published on: August 6, 2019

5.7K

Related Experiment Videos

Last Updated: May 27, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

7.7K
An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

17.3K
Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
08:09

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery

Published on: August 6, 2019

5.7K

Area of Science:

  • Polymer Science
  • Materials Science
  • Biomedical Engineering

Background:

  • Supramolecular polymers are built using reversible non-covalent interactions.
  • They possess unique properties like environmental responsiveness and self-healing.
  • These polymers are advantageous over conventional ones due to degradability and ease of functionalization.

Purpose of the Study:

  • To review recent advancements in supramolecular polymers for drug delivery.
  • To focus on design, properties, and applications in various therapeutic areas.
  • To highlight future research directions for enhanced drug delivery systems.

Main Methods:

  • Comprehensive literature review of supramolecular polymer applications in drug delivery.
  • Analysis of studies focusing on polymer design, synthesis, and characterization.
  • Evaluation of supramolecular polymers for small molecule, gene, and protein delivery.

Main Results:

  • Supramolecular polymers demonstrate significant potential for intelligent drug delivery.
  • Their responsiveness to biological stimuli is key for targeted therapies.
  • Recent research shows promise in overcoming challenges in drug delivery systems.

Conclusions:

  • Supramolecular polymers are versatile platforms for advanced drug delivery.
  • Future developments will focus on multifunctionality, adaptability, and personalized medicine.
  • These materials offer innovative solutions for treating complex diseases.