Associations between psoriasis, psoriatic arthritis and gout or hyperuricemia: A systematic review and meta-analysis

Uric acid (UA) has been associated with an increased incidence of psoriasis (PsO) and psoriatic arthritis (PsA). Clinical evidence shows that patients with PsO often have elevated serum UA levels, contributing to HUA and gout. This study investigated the bidirectional relationships among hyperuricemia (HUA), gout, PsO, and PsA through a systematic review and meta-analysis.

To evaluate the associations between PsO, PsA, and the risks of HUA and gout.

PubMed, Embase, CNKI, and Wanfang databases were searched for relevant literature published from databases inception until February 2024.Quality was assessed using the Newcastle-Ottawa Scale (NOS).

A total of 8 studies were included. Eligible studies included case-control, cohort, and cross-sectional studies.The meta-analysis showed that patients with PsO had a 2.56-fold higher risk of HUA [OR = 2.56, 95 % CI (1.82-3.59)] while PsA patients had a 3.56-fold higher risk of HUA [OR = 3.56, 95 % CI (2.04-6.20)]. The risk of gout was 4.95 times higher in PsA [OR = 4.95, 95 % CI (2.72-9.01)] and 1.95 times higher in PsO [OR = 1.95, 95 % CI (1.02-3.75)].

This study demonstrated a bidirectional relationship between psoriasis, psoriatic arthritis and gout or hyperuricemia, highlighting the need for clinicians to consider these conditions in managing the studied diseases.