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Published on: November 27, 2019
Acute-on-chronic liver failure (ACLF): the 'Kyoto Consensus'-steps from Asia
Ashok Choudhury1, Anand V Kulkarni2, Vinod Arora1
1Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India.
Hepatology International
|February 17, 2025
Summary
Acute-on-chronic liver failure (ACLF) is a life-threatening condition. A global consensus, the Kyoto APASL Consensus, was developed to standardize ACLF definitions and management, aiming for improved patient outcomes.
Area of Science:
- Hepatology
- Gastroenterology
- Critical Care Medicine
Background:
- Acute-on-chronic liver failure (ACLF) presents a significant mortality challenge globally.
- Diverse definitions and prognostic scores exist, including APASL ACLF Research Consortium (AARC), EASL CLIF, and NACSELD.
- Previous research has identified key factors like organ failure and infection in ACLF development.
Purpose of the Study:
- To establish a global consensus on the definition and management of ACLF.
- To integrate existing knowledge and address discrepancies in ACLF criteria.
- To provide evidence-based recommendations for improved patient care.
Main Methods:
- Convening global stakeholders, including APASL, EASL, and AASLD representatives.
- Reviewing existing ACLF databases and research, including the AARC database (10,500+ cases).
- Developing consensus recommendations through expert discussion and presentation at the APASL annual meeting in Kyoto.
Main Results:
- The 'Kyoto APASL Consensus' document presents final recommendations for ACLF.
- The consensus aims to unify definitions and management strategies.
- Identified areas for future research in ACLF.
Conclusions:
- A unified global approach to ACLF is crucial for improving outcomes.
- The Kyoto APASL Consensus provides a framework for standardized ACLF care.
- Further research is needed to refine ACLF management and treatment modalities.
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