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Clinicopathological significance of JAK2, STAT3, and STAT4 expression in patients with gastric solid-type poorly

Shinya Umekita1, Daisuke Kiyozawa1, Hitoshi Honma1

  • 1Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-Ku, Fukuoka, 812-8582, Japan.

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
|February 17, 2025
PubMed
Abstract

Insights

Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling is implicated in gastric cancer. High pSTAT3 and low STAT4 expression indicate poor prognosis in solid-type poorly differentiated adenocarcinoma.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • The role of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling in gastric solid-type poorly differentiated adenocarcinoma is not fully understood.
  • This study investigates the clinicopathological significance of JAK2, STAT3, and STAT4 expression in this cancer subtype.

Purpose of the Study:

  • To determine the clinicopathological significance of JAK2, STAT3, and STAT4 expression in gastric solid-type poorly differentiated adenocarcinoma.
  • To explore the association between these proteins, mismatch repair status, and patient prognosis.

Main Methods:

  • Retrospective analysis of 102 patients with primary solid-type poorly differentiated adenocarcinoma.
  • Immunohistochemical analysis of phosphorylated JAK2 (pJAK2), phosphorylated STAT3 (pSTAT3), and STAT4 expression.
  • Correlation of protein expression with mismatch repair status, clinicopathological characteristics, and survival outcomes.

Main Results:

  • Deficient mismatch repair was associated with higher pJAK2 and STAT4 expression compared to proficient mismatch repair.
  • High pSTAT3 and low STAT4 expression significantly correlated with reduced overall survival.
  • High pSTAT3 and low STAT4 expression, along with proficient mismatch repair status, were independent indicators of unfavorable prognosis.

Conclusions:

  • Increased pJAK2 and STAT4 expression is more prevalent in gastric solid-type poorly differentiated adenocarcinoma with deficient mismatch repair.
  • High pSTAT3 and low STAT4 expression may serve as valuable prognostic biomarkers for this cancer type.
Keywords:
JAK2MSIPDASTAT3STAT4

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