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[Deep mycoses in leukemias and malignant lymphomas].
Deutsche Medizinische Wochenschrift (1946)
|June 7, 1985
Summary
Deep-seated fungal infections (mycoses) are increasingly common in leukaemia and lymphoma patients, despite available treatments. These severe infections are influenced by cancer therapy, disease type, and supportive care intensity.
Area of Science:
- Medical Mycology
- Hematology
- Oncology
Context:
- Retrospective analysis of 590 autopsies (1976-1983) in patients with leukaemia and malignant lymphomas.
- Observed a 15% incidence of deep-seated mycoses (89 cases).
- Noted a considerable rise in mycotic infections in the last three years of the study period.
Purpose:
- To analyze the incidence and influencing factors of deep-seated mycoses in hematologic malignancies.
- To identify trends in fungal infections over an eight-year period.
Summary:
- Deep-seated mycoses occurred in 15% of autopsies for leukaemia and lymphoma patients.
- Candidosis and aspergillosis were the most frequent fungal infections.
- Severe mycoses (70% of cases) significantly impacted disease progression.
- Increased incidence noted in acute leukaemias, chronic myelogenous leukaemias, and high-grade non-Hodgkin lymphomas.
- Opportunistic fungal infections were rare in Hodgkin's disease and plasmocytoma.
Impact:
- Highlights the growing challenge of fungal infections in immunocompromised cancer patients.
- Identifies key factors influencing mycoses: antineoplastic therapy, underlying disease, and supportive care.
- Suggests a need for enhanced antifungal strategies and supportive care in managing hematologic malignancies.